Prolonged exposure to microgravity reduces the number and size of fibers in skeletal muscles and understanding how this happens is vital to future long-term space exploration. Multidisciplinary Approach to Analysis of the Functional Alterations Induced by Microgravity in Human Satellite Cells and Study of Possible Countermeasures (MYOGRAVITY) looks at molecular, cellular and functional changes in satellite cells, which are adult stem cells involved in the growth, maintenance and repair of skeletal muscle tissue. It also investigates the possible role of a particular gene, IGF-1, in counteracting these microgravity-induced muscle changes.

The goal of the Multidisciplinary Approach to Analysis of the Functional Alterations Induced by Microgravity in Human Satellite Cells and Study of Possible Countermeasures (MYOGRAVITY) investigation is to study the modifications induced by the exposure to microgravity, both simulated on ground by the use of a Random Positioning Machine (RPM), and real-time on board the International Space Station (ISS), in human muscle Satellite Cells (SCs) and their progeny, the myoblasts.

Molecular alterations and functional deficits of human muscle SCs are identified, consequent to the exposure to microgravity, and potentially linked to microgravity-induced muscle atrophy. The comparison between data obtained with human SCs and reported data obtained in murine SCs, make it possible to establish if murine SCs/myoblasts might be consider an affordable model in the study of human-related microgravity effects on muscle tissue. The comparison between data obtained from SCs cultivated in simulated vs real microgravity conditions is important to validate RPM as an affordable tool to artificially reproduce microgravity on the ground.

Mission: Expedition 51/52

Launch date: 14/08/2017 00:00:00

‣ News

THURSDAY 21 JULY 2022

ASTROSAMANTHA, THE FIRST EUROPEAN SPACEWALKER ‣

First extravehicular activity for Samantha Cristoforetti MORE...

TUESDAY 19 JULY 2022

AGILE, published the first article about the “New Year’s Burst” ‣

On Friday 15 July, the first detailed study on this "New Year's Burst" was published in the Astrophysical Journal, using data acquired by the AGILE satellite MORE...

MONDAY 11 JULY 2022

Fermi-LAT collaboration has released the updated list of cosmic gamma-ray sources to date ‣

The third release of the Fermi Point Source Catalog (4FGL-DR3) covers 12 years of data taken by the Large Area Telescope (LAT) on board of the Fermi Gamma-ray Space Telescope MORE...

WEDNESDAY 18 MAY 2022

SECOND MEETING IN SPACE WITH ASTROSAMANTHA ‣

The Italian experiments of the Minerva mission were presented MORE...

THURSDAY 28 APRIL 2022

Samantha Cristoforetti has arrived on the Space Station ‣

The hatch is opened: the Minerva mission kicks off. During her mission, the ESA astronaut will conduct several scientific experiments for the ASI

MORE...