{"id":16847,"date":"2019-06-26T16:56:09","date_gmt":"2019-06-26T14:56:09","guid":{"rendered":"https:\/\/www.asi.it\/?post_type=esperimenti&#038;p=16847"},"modified":"2020-04-23T11:45:42","modified_gmt":"2020-04-23T09:45:42","slug":"amyloid-aggregation","status":"publish","type":"esperimenti","link":"https:\/\/www.asi.it\/en\/esperimenti\/amyloid-aggregation\/","title":{"rendered":"Amyloid Aggregation"},"content":{"rendered":"<p class=\"p1\"><span class=\"s1\">The aim of the Amyloid Aggregation investigaton is to assess if amyloid fibrils aggregation is affected by microgravity in order to identify a possible professional risk in astronauts spending long periods on board the International Space Station (ISS).<\/span>\r\n<span class=\"s1\">Information obtained from this investigation allows for the identification of possible professional risks for astronauts employed in long-duration space missions. Furthermore, since protein accumulation is a predominant feature of many neurodegenerative diseases, a deeper comprehension of mechanism underlying peptides aggregation could be a crucial goal in neuroscience research.<\/span><span class=\"s1\">\u00a0 \u00a0\u00a0The performance of the Amyloid Aggregation investigation aboard the International Space Station (ISS) represents a unique opportunity to study how microgravity influences the \u201camyloid hypothesis\u201d, which asserts that amyloid fibrils or the formation of amyloid fibrils are a causative factor in onset and\/or progression of Alzheimer\u2019s Disease. In particular, the microgravity environment could help to understand two fundamental aspects of amyloid fibrillogenesis: the determination of the structure of the fibrils and the process of fibrils formation (i.e., mechanism and kinetics). Moreover, differences in results obtained between the experiments performed in space, and those performed in the laboratory on Earth, may shed light on the possibility of greater amyloid accumulation in the central nervous system (CNS) of astronauts. <\/span><span class=\"s1\">Risk assessment could highlight the necessity of implementing monitoring and prevention systems to protect astronauts on future long-duration space missions<\/span>. Furthermore, since protein accumulation is a predominant feature of many neurodegenerative diseases, a deeper comprehension of mechanism underlying peptides aggregation could be a crucial goal in neuroscience research.<\/p>\r\n\r\n<div class=\"page\" title=\"Page 24\">\r\n<div class=\"section\">\r\n<div class=\"layoutArea\">\r\n<div class=\"column\">\r\n\r\nThe performance of the Amyloid Aggregation investigation aboard the International Space Station (ISS) represents a unique opportunity to study how microgravity in uences the \u201camyloid hypothesis\u201d, which asserts that amyloid brils or the formation of amyloid brils are a causative factor in onset and\/or progression of Alzheimer\u2019s Disease. In particular, the microgravity environment could help to understand two fundamental aspects of amyloid brillogenesis: the determination of the structure of the brils and the process of brils formation (i.e., mechanism and kinetics).\r\n<div class=\"page\" title=\"Page 25\">\r\n<div class=\"section\">\r\n<div class=\"layoutArea\">\r\n<div class=\"column\">\r\n\r\nMoreover, di erences in results obtained between the experiments performed in space, and those performed in the laboratory on Earth, may shed light on the possibility of greater amyloid accumulation in the central nervous system (CNS) of astronauts.\r\n\r\nRisk assessment could highlight the necessity of implementing monitoring and prevention systems to protect astronauts on future long- duration space missions.\r\n\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<p class=\"p1\"><\/p>","protected":false},"author":3,"featured_media":0,"template":"","categories":[52],"class_list":["post-16847","esperimenti","type-esperimenti","status-publish","hentry","category-biology-and-biotechnology-en"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.9 (Yoast SEO v25.9) - 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